Billing and Coding: MolDX: Melanoma Risk Stratification Molecular Testing (A57290) - R4 - Effective October 1, 2025

Date Posted: October 23, 2025

This Billing and Coding Article has been revised under contract numbers: 02101 (AK), 02201 (ID), 02301 (OR), 02401 (WA), 03101 (AZ), 03201 (MT), 03301 (ND), 03401 (SD), 03501 (UT), and 03601 (WY).

Effective Date: October 1, 2025

Summary of Changes:

Under CPT/HCPCS Codes Group 1: Codes added 0578U. This revision is due to the 2025 Q4 CPT/HCPCS Code Update and is effective 10/1/2025.

Under CMS National Coverage Policy updated 3rd section heading. Under Article Text revised the 3rd and 6th bullets to remove "DEX Z-Code™" and replaced with "DEX Z-Code®". Added "NOTE: When entering the DEX Z-Code® on the SV101-7 documentation field for Part B claims please do not add additional characters and/or information on the line". This revision is effective 10/1/2025.

Visit the Noridian Molecular Diagnostic Services webpage to view the Active MolDX LCDs or access it via the CMS MCD.

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