ASC Payment System: July 2025 Update - Revised

Related CR Release Date: August 1, 2025 
MLN Matters Number: MM14101 Revised
Effective Date: July 1, 2025 
Related Change Request (CR) Number: CR 14101
Implementation Date: July 7, 2025 
Related CR Transmittal Numbers: R13259CP & R13344CP

Note: CMS revised this article to update the number of new HCPCS codes and coding information in the drugs, biologicals, and radiopharmaceuticals section. CMS also updated the CR release date, transmittal numbers, and transmittal links. Substantive content changes are in dark red (page 3).

CR 14101 tells you about:

  • Ambulatory Surgical Center (ASC) payment indicator (PI) change and new CPT code pairs for HCPCS code C1739
  • New CPT code pair for HCPCS code C1602
  • New CPT category III codes
  • Drugs, biologicals, and radiopharmaceuticals
  • Skin substitute products

Make sure your billing staff knows about these payment system updates effective July 1, 2025.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14101.

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