Hospital OPPS: October 2025 Update

Related CR Release Date: September 22, 2025
MLN Matters Number: MM14223
Effective Date: October 1, 2025 
Related Change Request (CR) Number: CR 14223
Implementation Date: October 6, 2025 
Related CR Transmittal Number: R13425CP

CR 14223 tells you about:

  • New COVID-19 monoclonal antibody and pleural-peritoneal shunt HCPCS codes
  • CPT proprietary laboratory analyses (PLA) and Hospital Outpatient Prospective Payment System (OPPS) device categories
  • Status indicator updates
  • Drugs, biologicals, and radiopharmaceuticals
  • Skin substitutes

Make sure your billing staff knows about these Hospital OPPS updates effective October 1, 2025.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14223.

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