CLFS Subject to Reasonable Charge Payment: October 2025 Update

Related CR Release Date: September 5, 2025
MLN Matters Number: MM14211
Effective Date: October 1, 2025 
Related Change Request (CR) Number: CR 14211
Implementation Date: October 6, 2025 
Related CR Transmittal Number: R13362CP 

CR 14211 tells you about:

  • When the next Clinical Laboratory Fee Schedule (CLFS) reporting period for clinical diagnostic laboratory tests (CDLTs) begins
  • New and deleted CPT codes effective October 1, 2025

Make sure your billing staff know about these changes.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14211.

Last Updated Sep 18 , 2025