Hospital OPPS: April 2026 Update

Number: 14380 
Release Date: March 13, 2026
Effective Date: April 1, 2026 
Implementation Date: April 6, 2026
Transmittal Number: R13686CP

CR 14308 tells you about:

  • New COVID-19 monoclonal antibody products and administration codes
  • New proprietary laboratory analyses (PLA) codes and Hospital OPPS device categories
  • Status indicator revisions and ambulatory payment classification assignments
  • Drugs, biologicals, and radiopharmaceuticals
  • Skin substitute products

Make sure your billing staff knows about these Hospital Outpatient Prospective Payment System (OPPS) updates, effective April 1, 2026.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14380.

Last Updated Mar 26 , 2026