Number: 14380 Revised 
Release Date: March 27, 2026
Effective Date: April 1, 2026 
Implementation Date: April 6, 2026
Transmittal Numbers: R13686CP & R13702CP

What’s Changed? CMS revised this article to change the status indicator for HCPCS code Q0599 from status indicator “E1” to status indicator “K.” CMS also updated the CR release date, transmittal numbers, and transmittal links. Substantive content changes are in dark red (page 5).

CR 14380 tells you about:

• New COVID-19 monoclonal antibody products and administration codes
• New proprietary laboratory analyses (PLA) codes and Hospital OPPS device categories
• Status indicator revisions and ambulatory payment classification assignments
• Drugs, biologicals, and radiopharmaceuticals
• Skin substitute products

Make sure your billing staff knows about this Hospital Outpatient Prospective Payment System (OPPS) updates, effective April 1, 2026.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14380.