National Fee Schedule for Vaccine Administration: October 2025 Update

Related CR Release Date: August 14, 2025 
MLN Matters Number: MM14195
Effective Date: January 24, 2025 & October 1, 2025
Related Change Request (CR) Number: CR 14195
Implementation Date: October 6, 2025 
Related CR Transmittal Number: R13365CP

CR 14195 tells you about coding updates for:

  • AVTOZMA® for post-exposure prophylaxis or COVID-19 treatment 
  • Newly FDA-approved products not yet assigned to a unique HCPCS Level II code

Make sure your billing staff knows about these changes.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14195.

Last Updated Sep 11 , 2025