Number: 14589 
Release Date: September 29, 2026 
Effective Date: October 1, 2026 
Implementation Date: October 5, 2026 
Transmittal Number: R13978CP

CR 14589 tells you about:

• CPT proprietary laboratory analyses (PLA) coding changes 
• New Category III CPT and HCPCS codes 
• Ambulatory payment classification (APC) assignment, descriptor, and status indicator changes 
• Drugs, biologicals, and radiopharmaceuticals 
• Skin substitute products 
• Qualifying non-opioid treatments for pain relief

Make sure your billing staff knows about Hospital Outpatient Prospective Payment System (OPPS) updates, effective October 1, 2026.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14589.