Billing and Coding: MolDX: Next-Generation Sequencing Lab-Developed Tests for Myeloid Malignancies and Suspected Myeloid Malignancies (A57891) - R14 - Effective October 1, 2026

Date Posted: September 24, 2026

This Billing and Coding Article has been revised under contract numbers: 02102 (AK), 02202 (ID), 02302 (OR), 02402 (WA), 03102 (AZ), 03202 (MT), 03302 (ND), 03402 (SD), 03502 (UT), and 03602 (WY).

Effective Date: Multiple dates

Summary of Changes:

Under ICD-10 Codes that Support Medical Necessity Group 1: Codes: added M04.3. This revision is due to the Annual ICD-10-CM Code Update and is effective 10/1/2026.

Under CPT/HCPCS Codes Group 1: Paragraph added "Inclusion does not imply coverage. Note: While 81455 and 81456 are genomic sequencing CPT® codes, they do not adequately define any particular service." Under CPT/HCPCS Codes Group 1: Codes added 81455 and 81456. This revision is effective 05/17/2020.

Visit the Noridian Molecular Diagnostic Services webpage to view the Active MolDX LCDs or access it via the CMS MCD.

Last Updated Sep 24 , 2026