Molecular Diagnostic Services

The Molecular Diagnostic Services (MolDX) Program was developed by Palmetto GBA in 2011 to identify and establish coverage and reimbursement for molecular diagnostic tests. This program performs the following functions.

  • Facilitates detailed and unique identification through registration of molecular diagnostic tests to facilitate claims processing and to track utilization.
  • Establishes clinical utility expectations.
  • Completes technical assessments of published test data to determine clinical utility and coverage.
  • Establishes reimbursement.

View the MolDX Molecular Test Registration and Claims Submission

View the MolDX: Molecular Test Registration Requirement for Hospital Laboratories

View the Molecular Diagnostic Program (MolDX®) Manual

View the DEX® registry

Palmetto GBA currently administers the MolDX Program and all its information.

Active LCDs - View all active Local Coverage Determinations (LCDs)

Proposed LCDs - View all proposed LCDs

Claim Submission Reminders

  • Submit only one DEX Z-Code™ identifier per CPT that requires one
  • Submit DEX Z-Code™ identifier in Loop 2400/SV101-7
  • If no DEX Z-Code™ identifier is submitted, CPT will deny unprocessable
  • Do not submit any other characters or test names. Doing so will slow claims processing and possibly cause incorrect denials


MolDX Contractor Noridian Providers in Noridian's Jurisdictions
  • Determinations regarding coverage
  • Pricing
  • Coordination with Change Healthcare to establish a unique identification numbers
  • Coordination/communication with Noridian on all claims processing guidelines
  • Implement MolDX guidelines in cooperation with MolDX contractor
  • Process claims using MolDX guidelines
  • Conduct Appeals/Reopenings for claims processing for Noridian providers
  • Continue to send new test documentation in regards to coverage consideration to MolDX contractor
  • Submit claims to Noridian after unique identifiers have been assigned
  • Send policy/coverage questions to Palmetto at
  • Contact Noridian Provider Contact Center with claims processing questions
  • Submit Reopening/Appeals requests to Noridian
Last Updated Jan 09 , 2024