Hospital OPPS: October 2025 Update

Related CR Release Date: September 22, 2025
MLN Matters Number: MM14223
Effective Date: October 1, 2025 
Related Change Request (CR) Number: CR 14223
Implementation Date: October 6, 2025 
Related CR Transmittal Number: R13425CP

CR 14223 tells you about:

  • New COVID-19 monoclonal antibody and pleural-peritoneal shunt HCPCS codes
  • CPT proprietary laboratory analyses (PLA) and Hospital Outpatient Prospective Payment System (OPPS) device categories
  • Status indicator updates
  • Drugs, biologicals, and radiopharmaceuticals
  • Skin substitutes

Make sure your billing staff knows about these Hospital OPPS updates effective October 1, 2025.

View the complete CMS Medicare Learning Network (MLN) Matters (MM)14223.

Last Updated Nov 20 , 2025